教师介绍页-j9在线平台

教授北京大学药学院
教师简介

叶新山

博士、教授、国家杰出青年基金获得者、973首席

有机化学,药物化学,化学糖生物学

电话 & 传真: 86-10-82805736

联系邮箱: [email protected]

学习经历:

1981-1985                 学士,武汉大学化学系

1985-1988                 硕士,武汉大学化学系

1993-1996            博士,香港中文大学化学系

1996-2000       博士后,美国scripps研究所

 

任职

1988-1993       讲师,华中农业大学

2000-           教授,北京大学

 

教学:          高等有机化学

 

研究方向与兴趣:

1)新的寡糖化学合成的方法和策略的发展;

2)生物活性寡糖(包括肿瘤相关糖抗原)的合成及活性评价;

3)氨基糖苷类抗生素的化学改造;

4)糖苷酶、糖基转移酶抑制剂的设计、合成、评价以及基于糖类的新药的发现。

 

主要学术兼职:

中国化学会化学生物学专业委员会委员,中国生物工程学会糖工程专业委员会委员,中国生物化学与分子生物学会复合糖专业委员会副主任委员,国家“重大新药创制”科技重大专项总体专家组成员。担任《有机化学》、《高等学校化学学报》、《中国药物化学杂志》、《中国新药杂志》、《北京大学学报(自然科学版)》等杂志的编委,担任《journal of chinese pharmaceutical sciences》杂志的副主编,担任国际杂志carbohydrate research的编委。

 

代表性论文:

1.xuefei huang, lijun huang, haisheng wang, xin-shan ye, “iterative one-pot synthesis of oligosaccharides”, angew. chem. int. ed., 2004, 43, 5221-5224.

2.haisheng wang, ji she, li-he zhang, xin-shan ye, “silver(i) oxide mediated selective monoprotection of diols in pyranosides”, j. org. chem., 2004, 69, 5774-5777.

3. yuhang wang, xuefei huang,  li-he zhang, xin-shan ye, “a four-component one-pot synthesis of α-gal pentasaccharide”, org. lett., 2004, 6, 4415-4417.

4.yuan wang, qin li, shuihong cheng, yanfen wu, dongjie guo, qiu-hua fan, xiaofang wang, li-he zhang, xin-shan ye, “base-promoted rearrangement of sugar epoxides to unsaturated sugars”, org. lett. 2005, 7, 5577-5579.

5.xin-shan ye, fang sun, min liu, qin li, yuhang wang, guisheng zhang, li-he zhang, xiao-lian zhang, “synthetic iminosugar derivatives as new potential immunosuppressive agents”, j. med. chem., 2005, 48, 3688-3691.

6.qiu-hua fan, nan-ting ni, qin li, li-he zhang, xin-shan ye, “new one-carbon degradative transformation of -azido alcohols”,-alkyl- org. lett. 2006, 8, 1007-1009.

7.jian zhou, guannan wang, li-he zhang, xin-shan ye, “modifications of aminoglycoside antibiotics targeting rna”, med. res. rev., 2007, 27, 279-316.

8.yiqun geng, li-he zhang, xin-shan ye,“pre-activation protocol leading to highly stereoselectivity-controllable glycosylations of oxazolidinone protected glucosamine donors, chem. commun., 2008, 597-599.

9. de-cai xiong, li-he zhang, and xin-shan ye*, “bromodimethylsulfonium bromide-silver triflate: a new powerful promoter system for the activation of thioglycosides”, adv. synth. catal. 2008, 350, 1696-1700.

10. yin-suo lu, qin li, li-he zhang, and xin-shan ye*, “highly direct α-selective glycosylations of 3,4-o-carbonate-protected 2-deoxy and 2,6-dideoxythioglycosides by preactivation protocol”, org. lett. 2008, 10, 3445-3448.

11.guan-nan wang, gabriele reinkensmeier, siwei zhang, jian zhou, liangren zhang, li-he zhang, terry d. butters* and xin-shan ye*, “rational design and synthesis of highly potent pharmacological chaperones for treatment of n370s mutant gaucher disease”, j. med. chem., 2009, 52, 3146-3149.

12. de-cai xiong, li-he zhang, and xin-shan ye*, “oxidant-controlled heck-type c-glycosylation of glycals with arylboronic acids: stereoselective synthesis of aryl 2-deoxy-c-glycosides”, org. lett., 2009, 11, 1709-1712.

13.lin yang and xin-shan ye*, “development of aminoglycoside antibiotics effective against resistant bacterial strains”, curr. top. med. chem., 2010, 10, 1898-1926.

14.fan yang, xiu-jing zheng, chang-xin huo, yue wang, ye zhang*, and xin-shan ye*, “enhancement of the immunogenicity of synthetic carbohydrate vaccines by chemical modifications of stn antigen”, acs chem. biol., 2011, 6, 252-259.

15.guan-nan wang, lin yang, li-he zhang, and xin-shan ye*, “a versatile approach to n-alkylated 1,4-dideoxy-1,4-imino-d-arabinitols and 1,4-dideoxy-1,4-imino-l-xylitols”, j. org. chem., 2011, 76, 2001-2009.

16.guan-nan wang, yulan xiong, jia ye, li-he zhang, and xin-shan ye*, “synthetic n-alkylated iminosugars as new potential immunosuppressive agents”, acs med. chem. lett. 2011, 2, 682-686.